Paraneoplastisches Cushing-Syndroms

Harvey Cushing

Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction

Ritonavir is commonly used in low doses to boost plasma levels of protease inhibitors in patients with human immunodeficiency virus (HIV) infections. It is also a potent inhibitor of cytochrome P450. We present a 50-year-old African American male with past medical history of HIV on highly active antiretroviral therapy (HAART), which also included ritonavir and long standing asthma that has been...

Cushing ' S Syndrome

In 1932 Harvey Cushing described a number of patients presenting a similar clinical picture which he had collected from the literature, and he added two more from his own records. The presence of minute adenomata of basophil cells in the anterior lobe of the pituitary gland was demonstrated at autopsy on some of them and Cushing regarded these as the causative lesions and called the syndrome 'p...

The Atypical Cushing Patient

Pituitary-induced bilateral adrenocortical hyperplasia also known as pituitary-dependent Cushing's disease (PDH) accounts for about 85% of all cases of spontaneous hypercortisolism in the dog. It results from either an adenohypophyseal ACTH-secreting microor macroadenoma or from excess pituitary ACTH secretion due to oversecretion of corticotrophin releasing factor (CRF) by the hypothalamus. Th...

Harvey Cushing, A Biography

The physician of today may be somewhat bewildered in the face of the vast current literature on penicillin and the conflicting views on methods of administration, dosages, and indications. Dr. Fleming and his 28 associates have now provided a most authoritative and yet practical guide-book concerning the place of this agent in medicine. No one will deny that much remains to be learned of penici...